The imbalance of the oral-facial muscles plays a fundamental role in the genesis of types of malocclusions, and in the occurrence of relapse at the end of orthodontic therapy. The treatment of patients affected by malocclusions associated with muscle-imbalance necessitates therefore a combined approach of orthodontic and myofunctional therapy. The Authors describe a specific program of muscular oro-facial functional reeducation based upon exercises to be thought to the patients at the beginning, middle and end of orthodontic treatment.