Role of dongchongxiacao (Cordyceps) in prevention of contrast-induced nephropathy in patients with stable angina pectoris

J Tradit Chin Med. 2013 Jun;33(3):283-6. doi: 10.1016/s0254-6272(13)60165-x.

Abstract

Objective: To study the preventative effects of Dongchongxiacao (Cordyceps) on contrast-induced nephropathy (CIN) in patients with stable angina pectoris (SAP).

Methods: One-hundred and three SAP inpatients were divided randomly into two groups: basic treatment (n = 51) and Dongchongxiacao (Cordyceps) treatment (n = 52); corbrin capsules (3 g; t.d.s.) were used 3 days before angioplasty and 3 days after angioplasty). Serum creatinine (Scr) was assessed at the time of hospital admission and 1, 2, and 3 days after angioplasty. Values of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) and interleukin (IL) 18 in the kidney were detected before angioplasty and 1 day after angioplasty in the patients of both groups. The prevalence of CIN between the two groups was then compared.

Results: CIN occurred in 9 of 103 patients (8.74%). The prevalence of CIN in the Dongchongxiacao (Cordyceps) treatment group was lower than that of the basic treatment group (5.77% vs 11.76%) but the difference was not significant (P > 0.05). The post-procedure mean peak of Scr, post-procedure increase in Scr levels from baseline, and urine levels of KIM-1, NGAL and IL18 after the procedure in the Dongchongxiacao (Cordyceps) treatment group were significantly lower than those in the basic treatment group (P < 0.05).

Conclusion: Prophylactic treatment with Dongchongxiacao (Cordyceps) in SAP patients who undergo coronary angiography or coronary intervention could prevent contrast-induced renal impairment.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute-Phase Proteins / urine
  • Adult
  • Aged
  • Angina, Stable / complications
  • Angina, Stable / diagnosis
  • Angina, Stable / diagnostic imaging*
  • Animals
  • Contrast Media / adverse effects*
  • Cordyceps / chemistry*
  • Coronary Angiography / adverse effects
  • Coronary Angiography / instrumentation
  • Creatinine / blood
  • Female
  • Hepatitis A Virus Cellular Receptor 1
  • Humans
  • Kidney Diseases / drug therapy
  • Kidney Diseases / etiology
  • Kidney Diseases / prevention & control*
  • Lipocalin-2
  • Lipocalins / urine
  • Male
  • Membrane Glycoproteins / urine
  • Middle Aged
  • Moths / chemistry*
  • Plant Preparations / administration & dosage*
  • Proto-Oncogene Proteins / urine
  • Radionuclide Imaging
  • Receptors, Virus
  • Young Adult

Substances

  • Acute-Phase Proteins
  • Contrast Media
  • HAVCR1 protein, human
  • Hepatitis A Virus Cellular Receptor 1
  • LCN2 protein, human
  • Lipocalin-2
  • Lipocalins
  • Membrane Glycoproteins
  • Plant Preparations
  • Proto-Oncogene Proteins
  • Receptors, Virus
  • Creatinine