Objective: To observe the effect of decoction for reinforcing lung Qi on T-lymphocytic function, interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) in peripheral blood of patients with non-small cell lung cancer after operation with argon helium lancet in order to explore its mechanism.
Methods: A total of 76 patients suffering from non-small cell lung cancer without surgical indication were randomly divided into a treatment group treated with decoction for reinforcing lung Qi and argon helium lancet and a control group treated with argon helium lancet only to observe lymphocytic proliferation, detect the percentage of positive cells in the T-lymphocyte CD28 with flow cytometry and detect the expression of IL-2 and TNF-alpha in peripheral blood with enzyme linked immunosorbent assay.
Results: Proliferation of T-lymphocytes and expression of CD28, IL-2 and TNF-alpha in peripheral blood after treatment in the treatment group were more obviously strengthened than those before treatment and those in the control group (all P < 0.05).
Conclusion: The mechanism of using decoction for reinforcing lung Qi and argon helium lancet to treat lung cancer may be realized through promoting T-lymphocytic proliferation, up-regulating expression of CD28, IL-2 and TNF-alpha, and activating T-cells.