Pharmacological effects of Astragaloside IV: a literature review

J Tradit Chin Med. 2013 Jun;33(3):413-6. doi: 10.1016/s0254-6272(13)60189-2.


Objective: To review the pharmacological effects and mechanisms of action of Astragaloside IV in Huangqi (Radix Astragali Mongolici).

Methods: Aticles focusing on Astragaloside IV in English and Chinese in databases were collected and reviewed in order to summarize the latest extraction separation, pharmacokinetics, and the pharmacological effects of astrageloside IV.

Results: Protective effects of Astrageloside IV on the cardiovascular system, immune, digestive, nervous system were identified, and the action mechanisms were associated with regulation of the calcium balance, anti-oxydant, antiapoptosis, antivirus, and so on.

Conclusion: Astrageloside IV has broad application prospects, especially in cardiovascular diseases, digestive diseases, cancer and other modern high incidence, high-risk diseases, and could be developed as a medicine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Astragalus propinquus / chemistry*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / pharmacology*
  • Humans
  • Phytotherapy
  • Saponins / chemistry
  • Saponins / pharmacology*
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*


  • Drugs, Chinese Herbal
  • Saponins
  • Triterpenes
  • astragaloside A