Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer

Genetics. 2013 Nov;195(3):1193-6. doi: 10.1534/genetics.113.156372. Epub 2013 Sep 11.


The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.

Keywords: Hippo signaling; LATS1; LATS2; human cancer; protein kinase.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Drosophila / genetics
  • Drosophila / growth & development
  • Female
  • Genes, Tumor Suppressor*
  • Humans
  • Male
  • Models, Genetic
  • Mutation
  • Neoplasms / genetics*
  • Protein Serine-Threonine Kinases / genetics*
  • RNA Interference
  • Tumor Suppressor Proteins / genetics*
  • Wings, Animal / growth & development


  • Tumor Suppressor Proteins
  • LATS1 protein, human
  • LATS2 protein, human
  • Protein Serine-Threonine Kinases