Selective serotonin reuptake inhibitors for stroke recovery

JAMA. 2013 Sep 11;310(10):1066-7. doi: 10.1001/jama.2013.107828.


Clinical question: Are selective serotonin reuptake inhibitors (SSRIs) associated with better recovery after stroke?

Bottom line: SSRIs may be associated with improved recovery after stroke, even in persons without depression. However, much of the evidence is of poor quality. Large, high-quality trials are needed to evaluate the validity of the current evidence and improve precision of estimates of any treatment benefits.

Publication types

  • Meta-Analysis

MeSH terms

  • Activities of Daily Living
  • Anxiety / drug therapy
  • Depression / drug therapy
  • Disabled Persons*
  • Humans
  • Randomized Controlled Trials as Topic
  • Recovery of Function
  • Serotonin Uptake Inhibitors / adverse effects
  • Serotonin Uptake Inhibitors / therapeutic use*
  • Stroke / drug therapy*
  • Stroke / nursing
  • Stroke / physiopathology
  • Treatment Outcome


  • Serotonin Uptake Inhibitors