Age-specific Mycoplasma pneumoniae pneumonia-associated myocardial damage in children

J Int Med Res. 2013 Oct;41(5):1716-23. doi: 10.1177/0300060513497559. Epub 2013 Sep 11.


Objective: To measure Mycoplasma pneumoniae pneumonia (MPP)-associated myocardial damage in different age groups of children with pneumonia.

Methods: Children aged 0-14 years with pneumonia and myocardial damage (serum creatine kinase isoenzyme-MB [CK-MB] concentration >25 U/l) were enrolled in the study. The children were classified as Mycoplasma pneumoniae immunoglobulin M positive (M. pneumoniae IgM+) or negative (M. pneumoniae IgM-) based on a serological test. Children were stratified into four age groups in order to analyse age-specific MPP-associated myocardial damage.

Results: The incidence of fever was significantly higher in children who were M. pneumoniae IgM+ compared with M. pneumoniae IgM- children. The median serum CK-MB concentration was significantly higher in children who were M. pneumoniae IgM+ compared with those who were M. pneumoniae IgM-. Children who were M. pneumoniae IgM+ in the 13-36 months and 72 months-14 years age groups had significantly higher median serum CK-MB concentrations than those who were M. pneumoniae IgM- in the same age group.

Conclusions: M. pneumoniae infection was associated with greater myocardial damage in children aged 13-36 months and 72 months-14 years. This suggests age-specific immune responses to M. pneumoniae.

Keywords: Mycoplasma pneumoniae; age; immune system; infection; myocardial injury.

MeSH terms

  • Adolescent
  • Age Factors
  • Antibodies, Bacterial / blood*
  • Child
  • Child, Preschool
  • Creatine Kinase, MB Form / blood
  • Female
  • Fever / microbiology
  • Fever / pathology
  • Humans
  • Immunoglobulin M / blood*
  • Infant
  • Infant, Newborn
  • Male
  • Mycoplasma pneumoniae / pathogenicity*
  • Mycoplasma pneumoniae / physiology
  • Myocarditis / blood
  • Myocarditis / complications
  • Myocarditis / microbiology
  • Myocarditis / pathology*
  • Myocardium / pathology*
  • Pneumonia, Mycoplasma / blood
  • Pneumonia, Mycoplasma / complications
  • Pneumonia, Mycoplasma / microbiology
  • Pneumonia, Mycoplasma / pathology*
  • Severity of Illness Index


  • Antibodies, Bacterial
  • Immunoglobulin M
  • Creatine Kinase, MB Form