Abstract
We describe the case of HIV-1 infected patient presenting to hospital with a severe cutaneous adverse drug reaction shortly after commencing dapsone therapy as Pneumocystis jirovecii pneumonia prophylaxis. To the best of our knowledge, acute generalised exanthematous pustulosis has not been reported as a reaction to dapsone in the setting of HIV.
Keywords:
AIDS; HIV; acute generalised exanthematous pustulosis; antiretroviral therapy; dapsone; drug reaction; toxicity.
MeSH terms
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AIDS-Related Opportunistic Infections / prevention & control*
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Acute Generalized Exanthematous Pustulosis / etiology*
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Acute Generalized Exanthematous Pustulosis / pathology
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Adult
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Anti-Infective Agents / adverse effects*
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Anti-Infective Agents / therapeutic use
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Antibiotic Prophylaxis / adverse effects*
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Biopsy
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Dapsone / adverse effects*
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Dapsone / therapeutic use
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HIV Infections / diagnosis
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Humans
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Pneumonia, Pneumocystis / prevention & control*
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Treatment Outcome
Substances
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Anti-Infective Agents
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Dapsone