Norbornenes in inverse electron-demand Diels-Alder reactions

Abstract

Significant differences in the reactivity of norbornene derivatives in the inverse electron-demand Diels-Alder reaction with tetrazines were revealed by kinetic studies. Substantial rate enhancement for the exo norbornene isomers was observed. Quantum-chemical calculations were used to rationalize and support the observed experimental data.

Keywords: inverse electron-demand Diels-Alder reactions; kinetics; norbornene; quantum-chemical calculations.