Immunological tolerance in human transplantation. The possible existence of a maternal effect

Transplantation. 1990 Sep;50(3):443-5. doi: 10.1097/00007890-199009000-00016.

Abstract

We analyzed data from 93 patients who received a kidney graft from their parents; 55 were transplanted with a kidney from their mothers (Mat.) and thirty-eight from their fathers (Pat.) The Pat. group has shown a better graft and patient survival as well as long-term renal function when compared with the Mat. group. This pattern was more evident with time. Long-term graft function assessed by creatinine levels also showed differences between the groups, favoring the Pat. group. The results are interesting since recent reports have claimed a tolerance developed by the individual to noninherited HLA antigens of their mother.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Female
  • Graft Survival / immunology
  • Humans
  • Immune Tolerance
  • Kidney Transplantation / immunology
  • Maternal-Fetal Exchange / immunology*
  • Middle Aged
  • Pregnancy
  • Survival Rate
  • Tissue Donors
  • Transplantation, Homologous / immunology*
  • Transplantation, Homologous / mortality