[The use of iontophoresis in corneal crosslinking technique]

Oftalmologia. 2013;57(1):3-8.
[Article in Romanian]


Iontophoresis is a method of facilitating the penetration of a drug through an intact tissue in the presence of an low intensity electrical current. In corneal crosslinking technique, iontophoresis is used for transepitelial impregnation of cornea with riboflavin. Compared to passive technique of corneal impregnation, iontophoresis shortens the time needed for impregnation, the time of exposure to UVA radiation and does not require de-epithelialisation.

Publication types

  • English Abstract

MeSH terms

  • Cornea / drug effects*
  • Cornea / pathology
  • Cross-Linking Reagents*
  • Humans
  • Iontophoresis / methods*
  • Keratoconus / drug therapy*
  • Keratoconus / metabolism
  • Photosensitizing Agents / therapeutic use*
  • Riboflavin / therapeutic use*
  • Treatment Outcome


  • Cross-Linking Reagents
  • Photosensitizing Agents
  • Riboflavin