Cuticular drusen: stars in the sky

Prog Retin Eye Res. 2013 Nov;37:90-113. doi: 10.1016/j.preteyeres.2013.08.003. Epub 2013 Sep 9.


Cuticular drusen is a specific clinical subtype of age-related macular degeneration (AMD). This subtype of AMD has an earlier age at onset, a stronger familial component, and genetic factors play a more prominent role in its development than in the general AMD population. In this review, we describe the clinical characteristics and differential diagnosis of cuticular drusen, as well as systemic associations including membranoproliferative glomerulonephritis type II. We discuss recent genetic and pathophysiological insights, and future therapeutic perspectives are highlighted.

Keywords: Age-related macular degeneration; Complement system; Cuticular drusen; Drusen; Genetics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Complement System Proteins / genetics
  • Diagnosis, Differential
  • Genetic Predisposition to Disease
  • Humans
  • Macular Degeneration* / diagnosis
  • Macular Degeneration* / genetics
  • Macular Degeneration* / pathology
  • Pigment Epithelium of Eye
  • Retinal Drusen* / diagnosis
  • Retinal Drusen* / genetics
  • Retinal Drusen* / pathology
  • Risk Factors


  • Complement System Proteins