Fusobacterium spp. and colorectal cancer: cause or consequence?

Temitope O Keku; Amber N McCoy; Andrea M Azcarate-Peril

doi:10.1016/j.tim.2013.08.004

Fusobacterium spp. and colorectal cancer: cause or consequence?

Trends Microbiol. 2013 Oct;21(10):506-8. doi: 10.1016/j.tim.2013.08.004. Epub 2013 Sep 9.

Authors

Temitope O Keku¹, Amber N McCoy, Andrea M Azcarate-Peril

Affiliation

¹ Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: tokeku@med.unc.edu.

Abstract

Although increasing evidence suggests a relationship between bacterial dysbiosis and colorectal cancer (CRC), few studies have identified specific microbial etiologic factors. Recent studies have implicated overabundance of Fusobacterium in association with colorectal adenomas and cancer. Two articles published in Cell Host & Microbe provide insights into the Fusobacterium-CRC relationship.

Publication types

Comment

MeSH terms

Adhesins, Bacterial / metabolism*
Animals
Cadherins / metabolism*
Carcinogenesis / immunology*
Colorectal Neoplasms / immunology*
Colorectal Neoplasms / microbiology*
Fusobacterium nucleatum / immunology*
Fusobacterium nucleatum / metabolism*
Fusobacterium nucleatum / pathogenicity*
Humans
Signal Transduction*
Virulence Factors / metabolism*
beta Catenin / metabolism*

Substances

Adhesins, Bacterial
Cadherins
Virulence Factors
beta Catenin

Abstract

Publication types

MeSH terms

Substances

Grants and funding