Time-dependent effects of chloroquine on pH of hepatocyte lysosomes

Biochem Pharmacol. 1990 Sep 15;40(6):1419-21. doi: 10.1016/0006-2952(90)90414-g.


In vivo administration of chloroquine to rats caused an increase in the pH of hepatocyte lysosomes within 1 hr after administration with a return to baseline pH values by 3 hr; continued administration of chloroquine for up to 12 days was unaccompanied by any further changes in hepatocyte lysosomal pH. We interpret these data as evidence against a major role for an increase in the pH of hepatocyte lysosomes in CAC-induced phospholipidosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chloroquine / pharmacology*
  • Hydrogen-Ion Concentration
  • Injections, Intraperitoneal
  • Liver / drug effects*
  • Lysosomes / drug effects*
  • Male
  • Rats
  • Rats, Inbred Strains


  • Chloroquine