The effect of a dentifrice containing Magnolia extract on established plaque and gingivitis in man: a six-month clinical study

Int J Dent Hyg. 2014 May;12(2):96-102. doi: 10.1111/idh.12047. Epub 2013 Aug 23.

Abstract

Aim: The aim was to evaluate the clinical effect of a dentifrice containing 0.3% Magnolia extract on dental plaque and gingivitis.

Material and methods: The trial was a 6-month double-blind, stratified, randomized and 2-armed parallel group study. Forty-six subjects in the test group brushed their teeth with a dentifrice containing 0.3% Magnolia extract and 48 subjects in the control group brushed with a placebo dentifrice. Plaque and gingivitis were assessed at baseline, 3 and 6 months.

Results: There was a significantly larger gingivitis reduction in the Magnolia group than in the control group (0.26 ± 0.11 versus 0.11 ± 0.12) (P < 0.001). There was a greater increase in the total number of healthy gingival units Gingival Index (GI score 0) in the Magnolia group than in the control group (149% versus 31%) and a larger reduction in inflamed gingival units (GI score 2/3) (60% versus 30%). Furthermore, at sites with similar amounts of plaque, less clinical signs of gingival inflammation were observed in the Magnolia group than in the control group.

Conclusion: Six months' unsupervised use of a dentifrice containing 0.3% Magnolia extract resulted in significantly greater gingivitis reduction than a corresponding control dentifrice.

Keywords: 6-month clinical study; Magnolia; dentifrice; gingivitis; plaque.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cariostatic Agents / therapeutic use
  • Dental Plaque / prevention & control*
  • Dental Plaque Index
  • Dentifrices / therapeutic use*
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Gingivitis / prevention & control*
  • Humans
  • Magnolia*
  • Male
  • Middle Aged
  • Periodontal Index
  • Phytotherapy / methods*
  • Placebos
  • Plant Extracts / therapeutic use*
  • Sodium Fluoride / therapeutic use
  • Toothbrushing / instrumentation
  • Young Adult

Substances

  • Cariostatic Agents
  • Dentifrices
  • Placebos
  • Plant Extracts
  • Sodium Fluoride