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. 2013 Sep 12;51(5):647-61.
doi: 10.1016/j.molcel.2013.08.022.

The Aurora B Kinase and the Polycomb Protein ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes

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The Aurora B Kinase and the Polycomb Protein ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes

Alberto Frangini et al. Mol Cell. .

Abstract

Reversible cellular quiescence is critical for developmental processes in metazoan organisms and is characterized by a reduction in cell size and transcriptional activity. We show that the Aurora B kinase and the polycomb protein Ring1B have essential roles in regulating transcriptionally active genes in quiescent lymphocytes. Ring1B and Aurora B bind to a wide range of active promoters in resting B and T cells. Conditional knockout of either protein results in reduced transcription and binding of RNA Pol II to promoter regions and decreased cell viability. Aurora B phosphorylates histone H3S28 at active promoters in resting B cells as well as inhibiting Ring1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes. Our results identify a mechanism for regulating transcription in quiescent cells that has implications for epigenetic regulation of the choice between proliferation and quiescence.

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