Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity

Cell Metab. 2013 Oct 1;18(4):478-89. doi: 10.1016/j.cmet.2013.08.008. Epub 2013 Sep 12.

Abstract

White and brown adipose tissues are hypervascularized and the adipose vasculature displays phenotypic and functional plasticity to coordinate with metabolic demands of adipocytes. Blood vessels not only supply nutrients and oxygen to nourish adipocytes, they also serve as a cellular reservoir to provide adipose precursor and stem cells that control adipose tissue mass and function. Multiple signaling molecules modulate the complex interplay between the vascular system and the adipocytes. Understanding fundamental mechanisms by which angiogenesis and vasculatures modulate adipocyte functions may provide new therapeutic options for treatment of obesity and metabolic disorders by targeting the adipose vasculature.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipocytes / cytology
  • Adipocytes / metabolism*
  • Angiogenesis Modulating Agents / metabolism
  • Cell Differentiation
  • Cytokines / metabolism
  • Endothelial Cells / cytology
  • Endothelial Cells / metabolism
  • Humans
  • Insulin Resistance
  • Neovascularization, Physiologic*
  • Obesity / metabolism*
  • Obesity / physiopathology
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Angiogenesis Modulating Agents
  • Cytokines
  • Vascular Endothelial Growth Factor A