Abstract
This review describes the functions, structures, and mechanisms of nine nickel-containing enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase, [NiFe]-hydrogenase, carbon monoxide dehydrogenase, acetyl-coenzyme A synthase/decarbonylase, methyl-coenzyme M reductase, and lactate racemase. These enzymes catalyze their various chemistries by using metallocenters of diverse structures, including mononuclear nickel, dinuclear nickel, nickel-iron heterodinuclear sites, more complex nickel-containing clusters, and nickel-tetrapyrroles. Selected other enzymes are active with nickel, but the physiological relevance of this metal specificity is unclear. Additional nickel-containing proteins of undefined function have been identified.
Keywords:
Catalytic mechanism; Enzyme; Metallocenter; Nickel; Protein structure.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Aldehyde Oxidoreductases / chemistry
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Aldehyde Oxidoreductases / metabolism
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Animals
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Bacteria / chemistry
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Bacteria / enzymology
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Dioxygenases / chemistry
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Dioxygenases / metabolism
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Enzymes / chemistry
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Enzymes / metabolism*
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Humans
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Hydrogenase / chemistry
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Hydrogenase / metabolism
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Lactoylglutathione Lyase / chemistry
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Lactoylglutathione Lyase / metabolism
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Models, Molecular
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Multienzyme Complexes / chemistry
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Multienzyme Complexes / metabolism
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Nickel / chemistry
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Nickel / metabolism*
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Oxidoreductases / chemistry
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Oxidoreductases / metabolism
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Protein Conformation
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Racemases and Epimerases / chemistry
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Racemases and Epimerases / metabolism
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Superoxide Dismutase / chemistry
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Superoxide Dismutase / metabolism
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Urease / chemistry
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Urease / metabolism
Substances
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Enzymes
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Multienzyme Complexes
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Nickel
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Oxidoreductases
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nickel-iron hydrogenase
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Hydrogenase
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Dioxygenases
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aci-reductone oxidase (CO-forming)
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Superoxide Dismutase
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Aldehyde Oxidoreductases
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carbon monoxide dehydrogenase
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methyl coenzyme M reductase
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Urease
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Lactoylglutathione Lyase
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Racemases and Epimerases
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lactate racemase