Metabolism of the malignant astrocytoma

Neurosurgery. 1990 Jan;26(1):1-19. doi: 10.1097/00006123-199001000-00001.


A comprehensive review of the biochemical organization of the malignant astrocytoma is presented. The review is intended for neurosurgeons. It outlines the metabolic flow of events beginning with energy and substrate utilization, followed by structural components (protein, lipids, etc.) and tumor cell secretory products, and ending with nucleic acid synthesis. Cellular pH, tumor-induced cerebral edema, tumor blood flow, and tumor necrosis are also considered.

Publication types

  • Review

MeSH terms

  • Astrocytoma / enzymology
  • Astrocytoma / genetics
  • Astrocytoma / metabolism*
  • Astrocytoma / pathology
  • Energy Metabolism
  • Glycolysis
  • Growth Substances / metabolism
  • Humans
  • Lipid Metabolism
  • Polyamines / metabolism
  • Protein Biosynthesis
  • Pyrimidines / metabolism


  • Growth Substances
  • Polyamines
  • Pyrimidines