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Editorial
. 2013;68(8):1074-6.
doi: 10.6061/clinics/2013(08)01.

Research on ionic homeostatic equilibrium may change our view about epilepsy

Maisa Ferreira Miranda  1 , Antônio Márcio Rodrigues, Esper A Cavalheiro, Fulvio A Scorza, Antônio Carlos G de Almeida
Affiliations
Editorial

Research on ionic homeostatic equilibrium may change our view about epilepsy

Maisa Ferreira Miranda et al. Clinics (Sao Paulo). 2013.
No abstract available

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Conflict of interest statement

No potential conflict of interest was reported.

Figures

Figure 1
Figure 1
Diagrammatic representation of conditions in which interference on synaptic transmission and/or non-synaptic mechanisms may affect seizures. Under normal ionic conditions, neuronal activity is not accompanied by important changes in the ionic concentrations (left). Therefore, the ionic gradients support effective actions of the synaptic transmission and non-synaptic mechanisms to reduce seizures. Conversely, when the transmembrane ionic gradients are decreased (right), the synaptic transmissions are depressed and the interferences on the synaptic circuit are refractory. However, seizure reduction is expected when interfering with the non-synaptic mechanisms to restore ionic gradients.
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