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Case Reports
. 2014 Jun;8(2):164-7.
doi: 10.1007/s12105-013-0489-1. Epub 2013 Sep 14.

Cherubism

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Free PMC article
Case Reports

Cherubism

Nurgül Kömerik et al. Head Neck Pathol. .
Free PMC article

Abstract

Cherubism is one of the very few genetically determined disorders that affect only jaw bones. A typical form of cherubism in an 11 years old girl with features of bilateral swelling of the cheeks and soap bubble radiographic appearance on the maxilla and the mandible was presented. Multiple members of the first and second degree relatives were also affected. The clinical presentation of the case, differential diagnosis and treatment modalities were discussed.

Figures

Fig. 1
Fig. 1
Right oblique view of the patient showing considerable bulging of both cheeks. Submandibular lymph enlargement can also be seen
Fig. 2
Fig. 2
Intraoral view of the patient showing malocclusion and malposition of the dentition together with bilateral obliteration of the vestibule sulcus due to sessile swellings
Fig. 3
Fig. 3
Panoramic radiograph of the patient is showing multilocular radiolucent lesions covering the entire body, ramus and angle of the mandible except condylar region. Note impacted and displaced teeth within the lesions
Fig. 4
Fig. 4
PET images of the patient superimposed on the coronal CT images revealing both maxillary and mandibular involvement. Note lytic hypermetabolic lesions at the posterior wall of the maxillary sinus, anterior maxilla, ramus regions
Fig. 5
Fig. 5
Microscopic view of the samples showing spindle-shaped fibroblasts and numerous osteoclast-like multinucleated giant cells (hematoxylin and eosin stain, ×200)

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