Horizontal gene transfer in eukaryotes: the weak-link model

Bioessays. 2013 Oct;35(10):868-75. doi: 10.1002/bies.201300007. Epub 2013 Aug 19.

Abstract

The significance of horizontal gene transfer (HGT) in eukaryotic evolution remains controversial. Although many eukaryotic genes are of bacterial origin, they are often interpreted as being derived from mitochondria or plastids. Because of their fixed gene pool and gene loss, however, mitochondria and plastids alone cannot adequately explain the presence of all, or even the majority, of bacterial genes in eukaryotes. Available data indicate that no insurmountable barrier to HGT exists, even in complex multicellular eukaryotes. In addition, the discovery of both recent and ancient HGT events in all major eukaryotic groups suggests that HGT has been a regular occurrence throughout the history of eukaryotic evolution. A model of HGT is proposed that suggests both unicellular and early developmental stages as likely entry points for foreign genes into multicellular eukaryotes.

Keywords: endosymbiosis; eukaryotic evolution; gene acquisition; genome evolution; organellar gene transfer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Eukaryota / genetics*
  • Evolution, Molecular
  • Gene Transfer, Horizontal*
  • Genes, Bacterial*
  • Mitochondria / genetics
  • Models, Genetic*
  • Phylogeny
  • Plastids / genetics
  • Symbiosis / genetics