Mechanisms of Muscle Growth and Atrophy in Mammals and Drosophila

Dev Dyn. 2014 Feb;243(2):201-15. doi: 10.1002/dvdy.24036. Epub 2013 Oct 24.

Abstract

Background: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy.

Results: In this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting.

Conclusions: Studies in Drosophila and mammals should help identify molecular targets for the treatment of muscle wasting in humans.

Keywords: animal models of muscle wasting; muscle atrophy; proteostasis; skeletal muscle growth.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila / physiology*
  • Inflammation / physiopathology
  • Mammals / physiology*
  • Models, Animal*
  • Models, Biological*
  • Muscle Development / physiology*
  • Muscular Atrophy / physiopathology*
  • Myostatin / metabolism
  • Neurodegenerative Diseases / physiopathology*
  • Oxidative Stress / physiology
  • Proteolysis
  • Signal Transduction / physiology*
  • Transcription Factors / metabolism

Substances

  • Myostatin
  • Transcription Factors