Virus-mimetic cytoplasm-cleavable magnetic/silica nanoclusters for enhanced gene delivery to mesenchymal stem cells

Angew Chem Int Ed Engl. 2013 Oct 18;52(43):11278-81. doi: 10.1002/anie.201301113. Epub 2013 Aug 28.


It does get in: Phage is made of DNA as a core and protein as a coat, and it can transfer DNA into host cells with high efficiency. Phage-mimetic gene transfer to hard-to-transfect mesenchymal stem cells (MSCs) was achieved using virus-mimetic magnetic silica nanoclusters (VMSNCs). The VMSNCs bear MSC-homing phage-borne protein on the surface and encapsulate DNA inside, promoting the transfer of DNA into MSCs.

Keywords: gene delivery; nanoparticles; phage display; stem cells; virus mimetics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Survival
  • Gene Transfer Techniques
  • Magnetics / methods*
  • Mesenchymal Stem Cell Transplantation
  • Nanoparticles / chemistry*
  • Silicon Dioxide / chemistry*
  • Transfection
  • Viruses / chemistry*
  • Viruses / genetics*


  • Silicon Dioxide