Opsin, a structural model for olfactory receptors?

Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11021-4. doi: 10.1002/anie.201302374. Epub 2013 Aug 26.


Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.

Keywords: GPCR; homology modeling; olfactory receptor; protein structures; receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Models, Molecular
  • Olfactory Receptor Neurons / chemistry*
  • Olfactory Receptor Neurons / metabolism
  • Opsins / chemistry*
  • Opsins / metabolism
  • Receptors, G-Protein-Coupled / chemistry*
  • Receptors, G-Protein-Coupled / metabolism


  • Opsins
  • Receptors, G-Protein-Coupled