Mechanochemical properties of individual human telomeric RNA (TERRA) G-quadruplexes

Chembiochem. 2013 Oct 11;14(15):1931-5. doi: 10.1002/cbic.201300350. Epub 2013 Aug 26.

Abstract

Potential functions: By following the unfolding and refolding of individual human RNA telomeric (TERRA) G-quadruplexes (GQs) in laser tweezers, the mechanical stability and transition kinetics of RNA GQs are obtained. Comparison between TERRA and DNA GQs suggests their different regulatory capacities for processes associated with human telomeres.

Keywords: G-quadruplexes; RNA structures; TERRA; laser tweezers; mechanical stability; mechanochemistry; single molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Sequence
  • G-Quadruplexes*
  • Humans
  • Mechanical Phenomena*
  • Models, Molecular
  • RNA / chemistry*
  • RNA / genetics
  • Telomere / genetics*

Substances

  • RNA