Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L665-81. doi: 10.1152/ajplung.00232.2013. Epub 2013 Sep 13.


In this review we summarize recent major advances in our understanding on the molecular mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary barrier dysfunction, highlighting the role of immune cells, inflammatory and noninflammatory signaling events, mechanical noxae, and the affected cellular and molecular entities and functions. Furthermore, we address novel aspects of resolution and repair of ALI, as well as putative candidates for treatment of ALI, including pharmacological and cellular therapeutic means.

Keywords: alveolar-capillary barrier dysfunction; molecular mechanism; pharmacological and cell-based therapy; pulmonary edema; zaacute lung injury/acute respiratory distress syndrome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Lung Injury / physiopathology*
  • Animals
  • Blood-Air Barrier / physiopathology*
  • Capillaries / physiopathology*
  • Capillary Permeability*
  • Cell Communication
  • Humans
  • Pulmonary Alveoli / physiopathology*