Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 35 (1 Suppl), 69-74; discussion 74-5

Danazol. A Synthetic Steroid With Diverse Biologic Effects

Affiliations
  • PMID: 2404115
Review

Danazol. A Synthetic Steroid With Diverse Biologic Effects

W P Dmowski. J Reprod Med.

Abstract

Danocrine (danazol) is a synthetic steroid with multiple and diverse biologic effects. It exerts these effects by binding to steroid transport proteins in the circulation and to specific receptors in target tissues. Centrally, danazol inhibits gonadotropins, suppressing gametogenesis and steroidogenesis. Gonadal and adrenal steroidogenesis are suppressed further through danazol's direct effect on specific enzyme systems. Danazol also displays immunoregulatory effects both in vivo and in vitro. In endometriosis, danazol induces amenorrhea and a hypoestrogenic state, resulting in endometrial atrophy. The drug's direct binding to androgen and progesterone receptors in endometriotic tissue may contribute further to the suppression of endometriosis. In women with endometriosis who produce autoantibodies against endometrial cells and endometrial cell-derived phospholipids, histones and nucleotides, danazol may improve reproductive performance through the suppression of abnormal autoantibody levels. In several other autoimmune and genetic disorders danazol brings about a clinical improvement by lowering abnormal autoantibody production or by increasing the concentration of genetically deficient protein. In order to explore the full clinical potential of the drug and to better understand danazol's mechanism of action and especially its immunoregulatory effects in autoimmune diseases and endometriosis, further investigation is necessary.

Similar articles

  • Danazol in the Treatment of Endometriosis and Infertility
    WP Dmowski. Prog Clin Biol Res 112 Pt B, 167-86. PMID 6819580.
    Endometriosis is an enigmatic condition of unknown cause and poorly understood histogenesis. It affects women in their reproductive years limiting their fertility and ser …
  • Danazol
    VH Donaldson. Am J Med 87 (3N), 49N-55N. PMID 2486535. - Review
    Danazol is a synthetic attenuated androgen that can interfere with normal interactions between the pituitary-hypothalamic axis and the gonads. These effects are mediated …
  • Danazol Binding to Steroid Receptors in Human Uterine Endometrium
    T Tamaya et al. Fertil Steril 41 (5), 732-5. PMID 6714450.
    To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine en …
  • Anti-endometrial IgM Autoantibodies in Endometriotic Patients: A Preliminary Study
    T Tanaka et al. Clin Exp Obstet Gynecol 27 (2), 133-7. PMID 10968355.
    Japanese herbal medicines (Kampo medicines) are usually the third most popular choice among medicines for treatment of endometriosis in Japan. This traditional therapy is …
  • Danazol: Endocrine Pharmacology and Therapeutic Applications
    RL Barbieri et al. Am J Obstet Gynecol 141 (4), 453-63. PMID 7025640. - Review
    The options for the medical management of endometriosis have been expanded by the introduction of the synthetic steroid, danazol. The results of large clinical studies su …
See all similar articles

Cited by 2 PubMed Central articles

LinkOut - more resources

Feedback