Prognostic factors in patients with bladder carcinoma treated with definitive irradiation

Cancer. 1990 Feb 15;65(4):908-12. doi: 10.1002/1097-0142(19900215)65:4<908::aid-cncr2820650415>;2-z.


An analysis was performed of 116 patients with bladder carcinoma who completed definitive radiotherapy at a single institution. Patients were analyzed for survival and local control. The overall 5-year survival rate was 34%. A multivariate analysis of survival showed disease stage, hemoglobin level, histologic grade, and total dose to be significant factors in outcome. The local control rates for Stage A, B, C, and D patients were 26%, 36%, 18%, and 0%, respectively. The multivariate analysis revealed disease stage and pretreatment hemoglobin level to be significant predictors of local control. In patients unsuitable for surgery or current combined technique protocols, high-dose irradiation may offer some patients survival and local control. Furthermore, prognostic factors in this study may aid in the stratification necessary for current protocol designs.

Publication types

  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Hemoglobin A / analysis
  • Humans
  • Hydronephrosis / complications
  • Hydronephrosis / diagnosis
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / surgery
  • Neoplasm Staging
  • Prognosis
  • Radiotherapy Dosage
  • Urinary Bladder Neoplasms / blood
  • Urinary Bladder Neoplasms / mortality
  • Urinary Bladder Neoplasms / pathology
  • Urinary Bladder Neoplasms / radiotherapy*
  • Urinary Bladder Neoplasms / surgery


  • Hemoglobin A