The history of heart and heart-lung transplantation

Cardiovasc Clin. 1990;20(2):3-19.


The current success of heart and heart-lung transplantation is grounded in a long progression of experimental and clinical advances. Beginning with an isolated heart transplant performed as a technical exercise in 1905, slowly accumulated experimental efforts yielded solutions to problems involving technique, recipient and graft protection, post-transplant function and immunology, and provided a foundation for subsequent clinical applications. Clinical studies augmented these observations and addressed legal and logistic issues involved in human transplantation.

Publication types

  • Case Reports
  • Historical Article

MeSH terms

  • Animals
  • Dogs
  • Heart Transplantation / history*
  • Heart Transplantation / methods
  • Heart Transplantation / mortality
  • Heart-Lung Transplantation / history*
  • Heart-Lung Transplantation / methods
  • Heart-Lung Transplantation / mortality
  • History, 20th Century
  • Humans
  • Male
  • Middle Aged
  • Pan troglodytes
  • Survival Rate
  • Transplantation, Heterotopic / history