The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

Nat Immunol. 2013 Oct;14(10):978-85. doi: 10.1038/ni.2680. Epub 2013 Sep 18.


The skin is a highly complex organ interspersed with a variety of smaller organ-like structures and a plethora of cell types that together perform essential functions such as physical sensing, temperature control, barrier maintenance and immunity. In this Review, we outline many of the innate and adaptive immune cell types associated with the skin, focusing on the steady state in mice and men, and include a broad update of dendritic cell function and T cell surveillance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / immunology
  • Dendritic Cells / immunology*
  • Humans
  • Immunity, Innate
  • Immunologic Memory
  • Lymphocyte Subsets / immunology*
  • Skin / immunology*