A Drosophila approach to thyroid cancer therapeutics

Drug Discov Today Technol. Spring 2013;10(1):e65-71. doi: 10.1016/j.ddtec.2012.09.004.

Abstract

Thyroid neoplasias represent among the fastest growing cancers. While surgery has become the treatment of choice for most thyroid tumors, many require chemotherapy. In this review, we examine the contributions of work in the fruit fly Drosophila toward multiple endocrine neoplasia type 2 (MEN2), a Ret-based disease to which recent Drosophila models have proven useful both for understanding disease mechanism as well as helping identify new generation therapeutics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Disease Models, Animal*
  • Drosophila / genetics*
  • Drug Evaluation, Preclinical
  • Humans
  • Piperidines / pharmacology
  • Piperidines / therapeutic use
  • Proto-Oncogene Proteins c-ret / genetics*
  • Quinazolines / pharmacology
  • Quinazolines / therapeutic use
  • Thyroid Neoplasms / drug therapy*
  • Thyroid Neoplasms / genetics

Substances

  • Antineoplastic Agents
  • Piperidines
  • Quinazolines
  • Proto-Oncogene Proteins c-ret
  • N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine