Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report

Onkologie. 2013;36(9):498-500. doi: 10.1159/000354635. Epub 2013 Aug 19.


Background: Granulosa cell tumors (GCT) are malignant tumors of the sex cord stroma representing 5% of all malignant ovarian tumors. Their treatment is surgery, and rarely chemotherapy and radiotherapy. Recently, salvage treatment with aromatase inhibitors was suggested based on few reported clinical cases.

Case report: We present the case of a 61-year-old woman with unresectable recurrent GCT of the right ovary treated with the aromatase inhibitor letrozole. Tumor mass and peritoneal carcinomatosis decreased in size allowing almost complete surgical resection. The patient remained in complete clinical remission for at least 24 months after surgery while under letrozole.

Conclusion: Aromatase inhibitors represent an innovative treatment for these rare and refractory tumors offering promising results while avoiding toxic and marginally active chemotherapeutic agents.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Female
  • Granulosa Cell Tumor / diagnostic imaging*
  • Granulosa Cell Tumor / drug therapy*
  • Humans
  • Letrozole
  • Middle Aged
  • Nitriles / therapeutic use*
  • Ovarian Neoplasms / diagnostic imaging*
  • Ovarian Neoplasms / drug therapy*
  • Radiography
  • Treatment Outcome
  • Triazoles / therapeutic use*


  • Antineoplastic Agents
  • Nitriles
  • Triazoles
  • Letrozole