Local anesthesia of the genital mucosa with a lidocaine/prilocaine cream (EMLA) for laser treatment of condylomata acuminata: a placebo-controlled study

Obstet Gynecol. 1990 Feb;75(2):302-6.


The time of onset and duration of local anesthesia of a lidocaine/prilocaine cream (EMLA) applied to the genital mucosa were assessed in a double-blind study. Eighty women with condylomata on their genital mucosa were randomly allocated to either EMLA (N = 60) or placebo cream (N = 20) between 1-75 minutes before CO2 laser treatment. The pain was evaluated by the patient on a visual analogue scale. The most effective degree of anesthesia was achieved after 5-15 minutes' application of EMLA. The patients given EMLA, regardless of application time, felt significantly less pain than the patients given placebo. EMLA could provide an alternative to general anesthesia in patients with extensive condylomata on the genital mucosa.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Anesthetics, Local*
  • Condylomata Acuminata / surgery*
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Laser Therapy / methods*
  • Lidocaine*
  • Lidocaine, Prilocaine Drug Combination
  • Middle Aged
  • Prilocaine*
  • Randomized Controlled Trials as Topic
  • Vaginal Creams, Foams, and Jellies
  • Vulvar Neoplasms / surgery*


  • Anesthetics, Local
  • Drug Combinations
  • Lidocaine, Prilocaine Drug Combination
  • Vaginal Creams, Foams, and Jellies
  • Prilocaine
  • Lidocaine