Mechanisms of NOD-like receptor-associated inflammasome activation

Immunity. 2013 Sep 19;39(3):432-41. doi: 10.1016/j.immuni.2013.08.037.

Abstract

A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / immunology
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Apoptosis Regulatory Proteins / immunology
  • Apoptosis Regulatory Proteins / metabolism*
  • CARD Signaling Adaptor Proteins / immunology
  • CARD Signaling Adaptor Proteins / metabolism*
  • Calcium-Binding Proteins / immunology
  • Calcium-Binding Proteins / metabolism*
  • Carrier Proteins / immunology
  • Carrier Proteins / metabolism*
  • Caspase 1 / metabolism
  • Enzyme Activation
  • Humans
  • Inflammasomes / immunology*
  • Mice
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Neuronal Apoptosis-Inhibitory Protein / immunology
  • Neuronal Apoptosis-Inhibitory Protein / metabolism*
  • Receptors, Cytoplasmic and Nuclear / immunology
  • Signal Transduction

Substances

  • Adaptor Proteins, Signal Transducing
  • Apoptosis Regulatory Proteins
  • CARD Signaling Adaptor Proteins
  • Calcium-Binding Proteins
  • Carrier Proteins
  • Inflammasomes
  • NAIP protein, human
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRC4 protein, human
  • NLRP1 protein, human
  • NLRP3 protein, human
  • Neuronal Apoptosis-Inhibitory Protein
  • Receptors, Cytoplasmic and Nuclear
  • Caspase 1