Abstract
A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / immunology
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Apoptosis Regulatory Proteins / immunology
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Apoptosis Regulatory Proteins / metabolism*
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CARD Signaling Adaptor Proteins / immunology
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CARD Signaling Adaptor Proteins / metabolism*
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Calcium-Binding Proteins / immunology
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Calcium-Binding Proteins / metabolism*
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Carrier Proteins / immunology
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Carrier Proteins / metabolism*
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Caspase 1 / metabolism
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Enzyme Activation
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Humans
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Inflammasomes / immunology*
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Mice
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLR Proteins
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Neuronal Apoptosis-Inhibitory Protein / immunology
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Neuronal Apoptosis-Inhibitory Protein / metabolism*
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Receptors, Cytoplasmic and Nuclear / immunology
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Signal Transduction
Substances
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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CARD Signaling Adaptor Proteins
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Calcium-Binding Proteins
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Carrier Proteins
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Inflammasomes
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NAIP protein, human
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NLR Family, Pyrin Domain-Containing 3 Protein
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NLR Proteins
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NLRC4 protein, human
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NLRP1 protein, human
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NLRP3 protein, human
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Neuronal Apoptosis-Inhibitory Protein
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Receptors, Cytoplasmic and Nuclear
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Caspase 1