Gender aspects in type 2 diabetes mellitus and cardiometabolic risk

Best Pract Res Clin Endocrinol Metab. 2013 Aug;27(4):501-7. doi: 10.1016/j.beem.2013.05.006. Epub 2013 Jun 13.


Men are well known to have a higher risk than women for cardiovascular disease. In recent years, however, studies show adult men also have higher risk for type 2 diabetes, an observation which has important clinical implications, particularly in the public health arena. This chapter explores the relevant data underlying this observation, examines potential mechanisms including life course changes in insulin resistance and role of adiposity, and discusses relevant clinical implications and solutions.

Keywords: adiposity; ectopic fat; insulin resistance; lifestyle changes; sex hormones.

Publication types

  • Review

MeSH terms

  • Adiposity
  • Adult
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / ethnology
  • European Continental Ancestry Group
  • Female
  • Humans
  • Insulin Resistance
  • Life Style
  • Male
  • Middle Aged
  • Risk Factors
  • Sex Characteristics