Clinical significance of serum BAP, TRACP 5b and ICTP as bone metabolic markers for bone metastasis screening in lung cancer patients

Clin Chim Acta. 2013 Nov 15;426:102-7. doi: 10.1016/j.cca.2013.09.011. Epub 2013 Sep 19.

Abstract

Background: We investigated the clinical significance of serum bone-specific alkaline phosphatase (BAP), tartrate-resistant acid phosphatase isoform 5b (TRACP 5b) and type I collagen carboxyterminal telopeptide (ICTP) as bone metabolic markers for bone metastasis (BM) screening in lung cancer patients.

Methods: Newly diagnosed advanced lung cancer patients with (N = 130) and without (N = 135) BM were enrolled in the study. Serum BAP, TRACP 5b and ICTP were measured before the treatment.

Results: BAP, TRACP 5b and ICTP values were higher in patients with BM compared with patients without BM (all P < 0.0001). Area under ROC curve (AUC) of BAP, TRACP 5b and ICTP was 0.760, 0.753 and 0.835 (all P < 0.0001), respectively. The cut-off values for BAP, TRACP 5b and ICTP were 21.8 μg/l, 7.8 U/l and 8.8 μg/l, respectively. When TRACP 5b and ICTP were combined, AUC was elevated to 0.895 (P < 0.0001), and the cut-off values were TRACP 5b 7.6 U/l and ICTP 8.4 μg/l.

Conclusions: We conclude that serum BAP, TRACP 5b and ICTP may serve as useful tools for BM screening in lung cancer patients.

Keywords: Bone metabolic markers; Bone metastasis; Bone-specific alkaline phosphatase (BAP); Tartrate-resistant acid phosphatase isoform 5b (TRACP 5b); Type I collagen carboxyterminal telopeptide (ICTP).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Phosphatase / blood*
  • Adult
  • Aged
  • Aged, 80 and over
  • Alkaline Phosphatase / blood*
  • Biomarkers, Tumor / blood*
  • Bone Neoplasms / blood
  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / secondary*
  • Collagen Type I / blood*
  • Female
  • Humans
  • Isoenzymes / blood*
  • Lung Neoplasms / pathology*
  • Male
  • Middle Aged
  • Peptides / blood*
  • Tartrate-Resistant Acid Phosphatase
  • Young Adult

Substances

  • Biomarkers, Tumor
  • Collagen Type I
  • Isoenzymes
  • Peptides
  • collagen type I trimeric cross-linked peptide
  • Alkaline Phosphatase
  • ACP5 protein, human
  • Acid Phosphatase
  • Tartrate-Resistant Acid Phosphatase