Biomarkers for the management of pre-eclampsia in pregnant women

Indian J Med Res. 2013;138(1):60-7.


Pre-eclampsia (PE) is a pregnancy related disorder characterized by hypertension and proteinuria noticeable after 20 wk of gestation. It is a leading cause of maternal and foetal mortality and morbidity worldwide. The aetiology of the disease is unknown, but recent studies have revealed that this disorder appears to originate in placenta and is characterized by widespread maternal endothelial dysfunction. Till date, delivery of placenta is the only cure for the disease. So, there is a need for the identification of highly specific and sensitive biochemical markers that would allow early identification of patients at risk and thus help in providing proper prenatal care. Several promising biomarkers have been proposed, alone or in combination, that may help in predicting women who are likely to develop PE. Maternal serum concentrations of these biomarkers either increase or decrease in PE during gestation. This review focuses on the various biomarkers available and their utility in predicting pre-eclampsia.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins
  • Antigens, CD / blood
  • Biomarkers / blood*
  • Endoglin
  • Female
  • Galectins / blood
  • Humans
  • Lipocalin-2
  • Lipocalins / blood
  • Pre-Eclampsia / blood
  • Pre-Eclampsia / therapy*
  • Pregnancy
  • Pregnancy Proteins / blood
  • Pregnancy-Associated Plasma Protein-A / metabolism
  • Proto-Oncogene Proteins / blood
  • Receptors, Cell Surface / blood
  • Risk Factors
  • Vascular Endothelial Growth Factor A / blood
  • Vascular Endothelial Growth Factor Receptor-1 / blood


  • Acute-Phase Proteins
  • Antigens, CD
  • Biomarkers
  • ENG protein, human
  • Endoglin
  • Galectins
  • LCN2 protein, human
  • LGALS13 protein, human
  • Lipocalin-2
  • Lipocalins
  • Pregnancy Proteins
  • Proto-Oncogene Proteins
  • Receptors, Cell Surface
  • Vascular Endothelial Growth Factor A
  • FLT1 protein, human
  • Vascular Endothelial Growth Factor Receptor-1
  • Pregnancy-Associated Plasma Protein-A
  • PAPPA1 protein, human