Abstract
Synthesis of the C1-C25 ABC spiroketal ring system of spirastrellolides B and F has been executed. The synthetic strategy relied on radical cyclization, HWE olefination, (BDP)CuH conjugate reduction and spiro acetalization reactions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Macrolides / chemical synthesis*
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Macrolides / chemistry
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Molecular Conformation
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
Substances
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Macrolides
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Spiro Compounds
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spirastrellolide B
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spirastrellolide F methyl ester