Synthesis of the C1-C25 southern domain of spirastrellolides B and F

Org Biomol Chem. 2013 Nov 7;11(41):7218-31. doi: 10.1039/c3ob41345d.

Abstract

Synthesis of the C1-C25 ABC spiroketal ring system of spirastrellolides B and F has been executed. The synthetic strategy relied on radical cyclization, HWE olefination, (BDP)CuH conjugate reduction and spiro acetalization reactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Macrolides / chemical synthesis*
  • Macrolides / chemistry
  • Molecular Conformation
  • Spiro Compounds / chemical synthesis*
  • Spiro Compounds / chemistry

Substances

  • Macrolides
  • Spiro Compounds
  • spirastrellolide B
  • spirastrellolide F methyl ester