TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts

Clin Exp Rheumatol. May-Jun 2013;31(3 Suppl 77):54-6. Epub 2013 Sep 9.


Objectives: The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be associated with Behçet's disease (BD) in a European-derived cohort, but not in Middle Eastern patients is investigated in two other populations.

Methods: Two cohorts of BD patients and controls from Turkey (n=797) and Italy (n=633) were genotyped by sequence specific primer-polymerase chain reaction (SSP-PCR) or TaqMan q-PCR assays.

Results: Genotype and allele frequencies in TIRAP S180L (rs8177374) were not different between BD patients and controls in either ethnicity. Furthermore, a meta-analysis between the Turkish and the Italian BD cohorts did not reveal an association between this non-synonymous SNP in TIRAP and BD (meta-analysis OR=0.94, meta-analysis p=0.61, Q statistic heterogeneity p=0.11).

Conclusions: TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study.

Publication types

  • Meta-Analysis
  • Multicenter Study

MeSH terms

  • Adult
  • Behcet Syndrome / ethnology
  • Behcet Syndrome / genetics*
  • Behcet Syndrome / immunology
  • Chi-Square Distribution
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Italy / epidemiology
  • Male
  • Membrane Glycoproteins / genetics*
  • Odds Ratio
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Receptors, Interleukin-1 / genetics*
  • Risk Factors
  • Turkey / epidemiology


  • Membrane Glycoproteins
  • Receptors, Interleukin-1
  • TIRAP protein, human