Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

BMB Rep. 2013 Sep;46(9):460-4. doi: 10.5483/bmbrep.2013.46.9.228.

Abstract

The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF-β1 secretion is increased by androgen treatment in DP-6, whereas androgen-inducible TGF-β1 was significantly suppressed by the ROS-scavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF-β1 by androgen is mediated by ROS in hair follicle DPCs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcysteine / pharmacology
  • Androgens / pharmacology*
  • Animals
  • Cell Line
  • Dermis / cytology
  • Dermis / drug effects*
  • Dermis / metabolism
  • Hair Follicle
  • Hydrogen Peroxide / pharmacology
  • Rats
  • Reactive Oxygen Species / metabolism*
  • Receptors, Androgen / genetics
  • Receptors, Androgen / metabolism
  • Transforming Growth Factor beta1 / metabolism*

Substances

  • Androgens
  • Reactive Oxygen Species
  • Receptors, Androgen
  • Transforming Growth Factor beta1
  • Hydrogen Peroxide
  • Acetylcysteine