The maximum single dose of resistant maltodextrin that does not cause diarrhea in humans

J Nutr Sci Vitaminol (Tokyo). 2013;59(4):352-7. doi: 10.3177/jnsv.59.352.


The objective of the present study was to determine the maximum dose of resistant maltodextrin (Fibersol)-2, a non-viscous water-soluble dietary fiber), that does not induce transitory diarrhea. Ten healthy adult subjects (5 men and 5 women) ingested Fibersol-2 at increasing dose levels of 0.7, 0.8, 0.9, 1.0, and 1.1 g/kg body weight (bw). Each administration was separated from the previous dose by an interval of 1 wk. The highest dose level that did not cause diarrhea in any subject was regarded as the maximum non-effective level for a single dose. The results showed that no subject of either sex experienced diarrhea at dose levels of 0.7, 0.8, 0.9, or 1.0 g/kg bw. At the highest dose level of 1.1 g/kg bw, no female subject experienced diarrhea, whereas 1 male subject developed diarrhea with muddy stools 2 h after ingestion of the test substance. Consequently, the maximum non-effective level for a single dose of the resistant maltodextrin Fibersol-2 is 1.0 g/kg bw for men and >1.1 g/kg bw for women. Gastrointestinal symptoms were gurgling sounds in 4 subjects (7 events) and flatus in 5 subjects (9 events), although no association with dose level was observed. These symptoms were mild and transient and resolved without treatment.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Diarrhea / chemically induced*
  • Diarrhea / complications
  • Dietary Fiber / administration & dosage*
  • Dietary Fiber / adverse effects
  • Dietary Fiber / pharmacology
  • Dose-Response Relationship, Drug
  • Feces
  • Female
  • Gases
  • Humans
  • Male
  • Middle Aged
  • Polysaccharides / administration & dosage*
  • Polysaccharides / adverse effects
  • Polysaccharides / pharmacology
  • Sex Factors
  • Young Adult


  • Dietary Fiber
  • Gases
  • Polysaccharides
  • maltodextrin