The clinical utilization of circulating cell free DNA (CCFDNA) in blood of cancer patients

Int J Mol Sci. 2013 Sep 13;14(9):18925-58. doi: 10.3390/ijms140918925.


Qualitative and quantitative testing of circulating cell free DNA (CCFDNA) can be applied for the management of malignant and benign neoplasms. Detecting circulating DNA in cancer patients may help develop a DNA profile for early stage diagnosis in malignancies. The technical issues of obtaining, using, and analyzing CCFDNA from blood will be discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • DNA / blood*
  • DNA Methylation
  • Humans
  • Loss of Heterozygosity
  • Microsatellite Instability
  • Multiplex Polymerase Chain Reaction*
  • Neoplasms / blood
  • Neoplasms / diagnosis*
  • Neoplasms / genetics


  • DNA