Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades. The global spreading of chloroquine-resistant falciparum malaria brings about an increasing use of quinine. The ototoxicity of quinine can accurately be studied with ultrahigh frequency audiometry (up to 20 kHz). The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.