Response to comment on "Community-wide isoniazid preventive therapy drives drug-resistant tuberculosis: a model-based analysis"

Sci Transl Med. 2013 Sep 25;5(204):204lr4. doi: 10.1126/scitranslmed.3007442.


Our modeling work suggests that isoniazid preventive therapy (IPT) can be effective in reducing drug-sensitive tuberculosis (TB) and that the risk of IPT driving resistance can be reduced by improving the detection and rapid treatment of individuals with drug-resistant disease and by limiting IPT to those in whom the intervention will have the largest benefit.

Publication types

  • Letter
  • Comment

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • Humans
  • Isoniazid / therapeutic use*
  • Tuberculosis / drug therapy*


  • Antitubercular Agents
  • Isoniazid