Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: clinical findings

Ultrasonics. 2014 Jul;54(5):1170-7. doi: 10.1016/j.ultras.2013.08.017. Epub 2013 Sep 10.

Abstract

The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the "gold standard" for the assessment of osteoporosis (T-score<-2.5). BUSS wave parameters were studied in 331 postmenopausal women examined by 9 trained operators at 3 clinical sites with use of 3 devices. The efficiency of each BUSS parameter in osteoporosis detection was assessed using a receiver operating characteristic curve analysis. Area under the curve (AUC) for each of 10 parameters ranged from 58.1% to 70.2%. Using these parameters a linear classifier was derived which provided at its output 83.0% AUC, 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The results of this study confirm BUSS's capability to detect osteoporosis in postmenopausal women.

Keywords: Axial scanning; Bone quantitative ultrasound; Multi-frequency; Osteoporosis; Wave propagation parameters.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Absorptiometry, Photon
  • Aged
  • Aged, 80 and over
  • Body Mass Index
  • Bone Density
  • Bone Diseases, Metabolic / diagnostic imaging
  • Equipment Design
  • Female
  • Humans
  • Middle Aged
  • Osteoporosis, Postmenopausal / diagnostic imaging*
  • Sensitivity and Specificity
  • Ultrasonography / instrumentation*