Microvascular complications in adolescents with type 1 diabetes mellitus

J Clin Res Pediatr Endocrinol. 2013 Sep 10;5(3):145-9. doi: 10.4274/Jcrpe.994.

Abstract

Objective: Screening of complications is an important part of diabetes care. The aim of this study was to investigate diabetic complications and related risk factors in adolescents with type 1 diabetes mellitus (T1DM).

Methods: This cross-sectional study was conducted on type 1 diabetics who were over 11 years of age or had a diabetes duration of 2 years and included 155 adolescents with T1DM (67 male, 88 female). The mean age of the patients was 14.4±2.1 years. Mean diabetes duration was 6.3±2.9 years. The patients were screened for diabetic nephropathy, retinopathy and peripheral neuropathy.

Results: Mean glycosylated hemoglobin (HbA1c) level of the study group was 8.4%. The frequency of microalbuminuria and peripheral neuropathy were 16.1% and 0.6%, respectively. None of the patients had diabetic retinopathy. Dyslipidemia and hypertension rates were 30.3% and 12.3%, respectively. Risk factors associated with microalbuminuria were hypertension, higher HbA1c levels, longer diabetes duration and dyslipidemia.

Conclusion: Early diagnosis and treatment of hypertension and dyslipidemia as well as achieving a better metabolic control are important in prevention or postponement of complications in patients with T1DM. Yearly screening for diabetic nephropathy should be started 2 years after the onset of the diabetes.

MeSH terms

  • Adolescent
  • Albuminuria / diagnosis
  • Child
  • Cross-Sectional Studies
  • Diabetes Complications / diagnosis*
  • Diabetes Mellitus, Type 1 / complications
  • Diabetic Angiopathies / diagnosis*
  • Diabetic Nephropathies / diagnosis
  • Diabetic Retinopathy / diagnosis
  • Dyslipidemias / diagnosis
  • Dyslipidemias / drug therapy
  • Female
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Hypertension / diagnosis
  • Hypertension / drug therapy
  • Male
  • Risk Factors

Substances

  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human