B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities

Oncoimmunology. 2013 Jul 1;2(7):e24744. doi: 10.4161/onci.24744. Epub 2013 Apr 30.


A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.

Keywords: B7x; immunosuppression; myeloid-derived suppressor cells; receptor; tumor microenvironment.