Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment

Oncoimmunology. 2013 Jul 1;2(7):e24891. doi: 10.4161/onci.24891. Epub 2013 May 7.

Abstract

Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signaling axis within the tumor stroma could therefore inhibit local immunosuppression and improve the efficacy of immunotherapeutic regimens against pancreatic cancer.

Keywords: IL-6; STAT3; immunosuppression; myeloid-derived suppressor cells; pancreatic cancer stellate cells.